In Situ Clearance of a {orange:Proximal Shunt Malfunction}
A case report peer-reviewed in {orange:Surgical Neurology International}, capturing the {orange:first intraoperative ultrasonographic evidence} that the ReFlow flusher can clear a proximal shunt obstruction noninvasively.

{orange:Overview}
This single-case report, peer-reviewed in Surgical Neurology International, documents the first direct intraoperative evidence that a proximal shunt obstruction can be cleared noninvasively using the ReFlow flusher. The case involved a 5-year-old boy who developed hydrocephalus following a cerebral arteriovenous malformation rupture and was treated with a ventriculoperitoneal shunt fitted with the ReFlow flusher assist device.
At the conclusion of the shunt placement, the surgical team noted that the shunt valve reservoir would not refill, a sign of proximal obstruction. They depressed the ReFlow flusher manually and observed the result under live intraoperative ultrasound.
{orange:Key Findings}
- At conclusion of placing VP shunt with ReFlow, the shunt valve reservoir was noted to not refill.
- After manual depression of the ReFlow flusher, identified clearance of debris from the obstructed ventricular catheter allowing reestablished CSF flow through the shunt system under live intraoperative ultrasonography. Subsequently, there was return of brisk refill to the shunt valve reservoir.
{orange:Clinical Relevance}
Reported direct intraoperative ultrasonographic evidence of ReFlow's retrograde flushing mechanism clearing debris from an obstructed ventricular catheter and restoring CSF flow through the shunt system. While limited to a single intraoperative case, the study supports the mechanistic rationale for ReFlow as a potential in situ approach to addressing proximal catheter obstruction.
Porter Z, et al. (May 16, 2020) Surg Neurol Int. 2020;11:116. DOI 10.25259/SNI_156_2020
Read the paperFrequently Asked Questions
Common questions about ReFlow® technology, our clinical evidence, and the condition it's designed to treat.
Hydrocephalus is a condition where cerebrospinal fluid (CSF) accumulates in the brain's ventricles, often requiring a shunt to manage. Left untreated, it can cause serious neurological damage.
The ReFlow® Mini Flusher is implanted in-line with a standard shunt system. A simple, deliberate press of the dome sends less than half a millilitre of fluid toward the ventricular catheter to clear blockages and restore CSF flow, without surgery.
Yes. The ReFlow® Mini Flusher is FDA 510(k) cleared and CE Marked. The broader ReFlow System has also received two FDA Breakthrough Device Designations (2021 and 2025).
Under the direction of the treating physician, flushing can be performed by a trained healthcare professional in-clinic, or by a trained caregiver or adult patient in a non-clinical setting.
Flushing frequency is determined by the treating physician based on individual patient needs. ReFlow is designed to support both on-demand clearing and routine maintenance flushing.
Yes. ReFlow has been evaluated across multiple published studies and clinical case series, with over 30 patients implanted across leading US neurosurgical centres with up to 6 years of follow-up.
Yes. The device is designed to support a broad patient population, from infants to older adults, and has been studied specifically in pediatric hydrocephalus cohorts.
No. The procedure to attach the ReFlow Mini Flusher does not significantly alter the shunt implant technique or add a significant amount of time.
The ReFlow System Mini and ReFlow Mini Flusher are currently available in the United States.
Clinicians, patients, and partners can reach our team directly via the Contact page. We're always happy to discuss ReFlow® and the science behind our platform.



