Our Technology


Through engagement with hydrocephalus experts, the broader scientific community, as well as patients and families, Anuncia developed the ReFlow™ Ventricular System, designed to address one of the most common problems in shunt systems for treatment of hydrocephalus: a non-flowing shunt.

The ReFlow™ Flusher connects directly to the ReFlow™ Ventricular Catheter. Both are implanted under the scalp and connected to a flow regulating valve (not included). The ReFlow™ System works with programmable and non-programmable valves and abdominal catheters of most makes and models.

When there is CSF flow or the shunt is functioning normally, the Flusher is passive, and flow is regulated by the flow regulating valve. If the ReFlow™ catheter becomes blocked and fluid flow through the shunt system is reduced or stops, a press of the Flusher by a qualified clinician sends a small, controlled flush of fluid toward the ReFlow™ catheter in an effort to push out any blockages, open catheter flow holes, and restore flow.

The ReFlow™ System’s ventricular catheter has a ‘relief membrane’ backup feature. If the Flusher is not able to restore flow through the standard flow holes of the ventricular catheter, the small, controlled pulse of fluid from the flusher is designed and tested to open the ‘relief membrane’ to make an additional opening in the Ventricular Catheter and re-establish flow. The ‘relief membrane’ backup feature may only be used once. After opening, it may become blocked in a manner similar to catheter flow holes.

  • After implanting a CSF shunt system, the ventricular catheter may become blocked, preventing fluid flow through the shunt system.
  • Without surgery, a clinician presses the ReFlow™ flusher to send a calibrated and safe flush of fluid towards the ReFlow™ catheter.
  • Blockages may be pushed out to open catheter flow holes and restore flow.
  • If the catheter flow holes remain blocked, the ReFlow™ flush opens the ReFlow™ Catheter ‘relief membrane’ backup feature.

The ReFlow™ does not change standard of care practices for the diagnosis, treatment, or follow-up of patients with ventricular catheter occlusions.

What does this mean for patients with shunts?

Hydrocephalus requires better solutions to prevent readmissions and revision surgeries for shunt patency failures. The Anuncia ReFlow™ Ventricular System is designed to be used noninvasively as means to potentially restore shunt system flow due to a blocked ventricular catheter without emergency surgery and reduce the burden of repeat brain surgeries for these patients, their families, and the healthcare system.

This system represents a first step toward a new generation of CSF management devices with advanced technological features engineered to empower clinicians to help break the cycle of endless shunt malfunctions and emergency shunt revision surgeries.

We are expanding our technology platforms to further impact the treatment of hydrocephalus.